catbirdseat Posted February 24, 2006 Posted February 24, 2006 I just read about a clever experiment using knockout mice at UW that showed how norepinephrine is responsible for the rewarding effect of morphine and not the usual suspect dopamine. Dopamine is converted to norepinephrine by an enzyme in a single step. When the converting enzyme was knocked out, the rewarding effect of morphine was lost. Doubtless norepinephrine is involved in the reward for climbing as well. So next time you are halfway up some north face with that shit-eating grin (or when you shoot up- if that's your thing), just remember, its the norepinephrine. Quote
olyclimber Posted February 24, 2006 Posted February 24, 2006 http://taosecurity.blogspot.com/2006/02/bears-teach-network-security.html Quote
Johnny_Tuff Posted February 24, 2006 Posted February 24, 2006 I just read about a clever experiment using knockout mice at UW that showed how norepinephrine is responsible for the rewarding effect of morphine and not the usual suspect dopamine. Dopamine is converted to norepinephrine by an enzyme in a single step. When the converting enzyme was knocked out, the rewarding effect of morphine was lost. Doubtless norepinephrine is involved in the reward for climbing as well. So next time you are halfway up some north face with that shit-eating grin (or when you shoot up- if that's your thing), just remember, its the norepinephrine. And to think some people find the sciences uninteresting, or even boring! Why, if that doesn't knock off your socks and curl your hair, you don't have a pulse! Quote
catbirdseat Posted February 24, 2006 Author Posted February 24, 2006 I just read about a clever experiment using knockout mice at UW that showed how norepinephrine is responsible for the rewarding effect of morphine and not the usual suspect dopamine. Dopamine is converted to norepinephrine by an enzyme in a single step. When the converting enzyme was knocked out, the rewarding effect of morphine was lost. Doubtless norepinephrine is involved in the reward for climbing as well. So next time you are halfway up some north face with that shit-eating grin (or when you shoot up- if that's your thing), just remember, its the norepinephrine. And to think some people find the sciences uninteresting, or even boring! Why, if that doesn't knock off your socks and curl your hair, you don't have a pulse! Okay, you want to know the interesting part? The mice don't need norepinephrine to survive after they are born. So if you can come up with a drug that blocks the converting enzyme, you have a possible treatment for addiction, that is free of side-effects. Quote
Johnny_Tuff Posted February 24, 2006 Posted February 24, 2006 Or Playboy Mansion poolside babe attacks? Quote
knotzen Posted February 25, 2006 Posted February 25, 2006 Speaking of dopamine, I take this drug, Mirapex (designed for Parkinson's Disease, but also works for restless leg syndrome, which is why I take it). Turns out it can cause a gambling addiction. Something to do with triggering dopamine, but not balancing it with seratonin or somesuch shit. Anyway, I'll bet anyone 10 to 1 that it's not affecting me that way, though. Quote
knotzen Posted February 25, 2006 Posted February 25, 2006 OK, speaking of ketchup... http://www.ketchupeffect.com/ketchupeffect.wmv Quote
Dru Posted February 25, 2006 Posted February 25, 2006 You take medication to stop restless leg, and end up gamboling. Typical. Quote
knotzen Posted February 25, 2006 Posted February 25, 2006 I know a lot of hikers with compulsive gamboling habits. It's a shame, really. Quote
Dru Posted February 25, 2006 Posted February 25, 2006 I had no shoes, and bemoaned my fate until I met a man with no feet. Then we both made fun of a retard and felt better. Quote
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