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Why is it that in the negative ion mode the LC/MS gives predominantly 2M-H for carboxylic acids, rather than M-H? Geek_em8.gif

For the same reason you biochem people use wavenumbers?

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Why is it that in the negative ion mode the LC/MS gives predominantly 2M-H for carboxylic acids, rather than M-H? Geek_em8.gif

 

Because deep deep down, the LC/MS is actually into group things.

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The LC/MS is still mad at you. You shouldn't have said it was fat.
I should think of some Rodney Dangerfield joke. "Folks, I gotta tell 'ya, I'm so bad with women, I can't even get along with Bertha the LC/MS."

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