Great boots, plenty of ankle mobility for climbing, warm enough (for me) for spring conditions in Colorado, although not for full on winter. I have added a toe cap to keep my feet dryer (no idea why La Sportiva didn't do this). The lacing system is better than the old Trango Extremes (hooks by the ankles instead of eyelets). However, the forefoot doesn't seem to tighten as narrow as the older style Trango Extremes, but this has not been a problem. You can really crank on the laces and tighten the ankle a little too much if your not careful. The new Trango Extreme S also seems a tad wider in the forefoot, and has a better heel fit (for me), more contoured and not as straight a heel as the older Trango series which were heel biters to me. I'm not too fond of the leather they are using, I would also prefer a roughout leather that would accept waterproofing better, as the old Trango extremes did. The yellow leather in the new boots seems thinner (lighter as well though), won't wear as well, and doesn't "take" nikwax as well....too early to tell on longevity of the upper. They have held up to small stream crossings fine.
My only complaint is I am on my 2nd pair in 5 weeks from delamination issues.....The first pair each delaminated the sole back 2-3" from the toe after 50 miles (returned to REI). The second (new) pair delaminated after a single 10 mile day, half of which was on snow. La sportiva is supposed to be fixing this pair under warrenty...we'll see. Its not like I'm hard on boots...I only wt. 140 lbs! So watch the toe area for delamination. My wife also has a pair and and has not experienced any delamination over the same period of time/trips.
Good luck, if they fit your foot, you'll like'em.